-Doxycycline has been found clinically effective in the treatment of a variety 

of infections caused by susceptible strains of Gram-positive and Gram-negative 

bacteria and certain other micro-organisms.
-Respiratory tract infections: Pneumonia and other lower respiratory tract infections

 due to susceptible strains of Streptococcus pneumoniae, Haemophilus influenzae, 

Klebsiella pneumoniae and other organisms. Mycoplasma pneumoniae pneumonia. 

Treatment of chronic bronchitis, sinusitis.
-Urinary tract infections: caused by susceptible strains of Klebsiella species, 

Enterobacter species, Escherichia coli, Streptococcus faecalis and other organisms.
-Sexually transmitted diseases: Infections due to Chlamydia trachomatis including

 uncomplicated urethral, endocervical or rectal infections. Non-gonococcal, urethritis

 caused by Ureaplasma urealyticum (T-mycoplasma). Doxycycline Capsules are also 

indicated in chancroid, granuloma inguinale and lymphogranuloma venereum .

 Doxycycline is an alternative drug in the treatment of gonorrhoea and syphilis.
-Skin infections: Acne vulgaris when antibiotic therapy is considered necessary.
-Since doxycycline is a member of the tetracycline series of antibiotics, it may be 

expected to be useful in the treatment of infections which respond to other tetracyclines, such as:
-Ophthalmic infections: Due to susceptible strains of gonococci, staphylococci and

 Haemophilus influenzae. Trachoma, although the infectious agent, as judged

 by immunofluorescence, is not always eliminated. Inclusion conjunctivitis may be 

treated with oral Doxycycline alone or in combination with topical agents.
-Rickettsial infections: Rocky Mountain spotted fever, typhus group, Q fever and

 Coxiella endocarditis and tick fevers.
-Other infections: Psittacosis, brucellosis (in combination with streptomycin),

 cholera, bubonic plague, louse and tick-borne relapsing fever, tularaemia glanders, 

melioidosis, chloroquine-resistant falciparum malaria and acute intestinal

 amoebiasis (as an adjunct to amoebicides).
-Doxycycline is an alternative drug in the treatment of leptospirosis, 

gas gangrene and tetanus.
-Doxycycline Capsules are indicated for prophylaxis in the following conditions: 

Scrub typhus, travellers diarrhoea (enterotoxigenic Escherichia coli), leptospirosis 

and malaria. Prophylaxis of malaria should be used in accordance to current guidelines, 

as resistance is an ever changing problem.
-Consideration should be given to official guidance on the appropriate use of antibacterial agents.